![]() Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. The BUN:creatinine ratio (BCR) is a calcu- lated laboratory value that has been used to discriminate between intrinsic and reversible decline in kidney function. It helps them see how well your kidneys are working. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. 6 min read Doctors order a blood urea nitrogen (BUN) test to measure the amount of urea nitrogen in your blood. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Again, azotemia is an elevation of creatinine and BUN, which can be pre-renal, renal, or post-renal in nature. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. ![]() Interpretation īUN is an indication of renal (kidney) health. It is not considered as reliable as creatinine or BUN/creatinine ratio blood studies. The test is used to detect renal problems. Individual laboratories will have different reference ranges, as the assay used can vary between laboratories. Normal human adult blood should contain 6 to 20 mg/dL (2.1 to 7.1 mmol/L) of urea nitrogen. The liver produces urea in the urea cycle as a waste product of the digestion of protein. Thus, a healthy individual typically has serum BUN levels higher than serum creatinine levels. If kidney disease is a possible diagnosis, doctors will order BUN and creatinine testing at the same time. The test may also be used to gauge how effective treatment has been. Normally, your kidneys filter creatinine from your blood and remove it from your body in your urine. Patients with kidney or liver disease will have BUN tests regularly to evaluate organ health and disease progression. It's made when you use your muscles and some of the muscle tissue breaks down. Creatinine is a normal waste product in your body. We concluded that the normal range of BUN and Cr levels differed between young and elderly subjects, and that the decline in renal function correlated with age after the seventh decade.6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood. creatinine is filtered and then secreted in the lumen. This test measures creatinine levels in a sample of your blood and/or urine (pee). Although Cr levels did not correlate with age in elderly subjects, Cr levels divided by body surface area significantly correlated with age. Significant positive correlation was found between BUN levels and age in male elderly subjects. The normal value of BUN can range from 7 20 mg/dL. The mean Cr level in the elderly subjects was slightly higher than that in the control subjects. The normal range for BUN, serum creatinine vary among laboratories. The mean BUN level in the elderly subjects was significantly higher than that in the control young subjects. ![]() The estimated normal range of BUN was 14-23 mg/dl both in male and female elderly subjects, and that of Cr was 0.9-1.3 mg/dl in male and was 0.7-1.1 mg/dl in female. ![]() We defined the normal range as range within the single SD-line of the remainder. We calculated the mean and the standard deviation (SD) in each group, and excluded subjects with values beyond twice the SD-line. This study was a part of the Kahoku Longitudinal Aging Study (KLAS) that aims to reveal the comprehensive functions in the aged. We measured the variables also in 315 cases of sex-matched young control subjects (male, 139 female, 176). In this situation a protein:creatinine (UPC) ratio up to 2.0 in both. To estimate normal ranges of blood urea nitrogen (BUN) and serum creatinine (Cr) levels in the aged, we measured BUN and Cr levels in 332 cases of apparent-healthy elderly subjects (male, 152 female, 180) aged 70 years or more. Normal BUN and creatinine values suggest the kidneys are likely healthy and working well. ![]()
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